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Home | CENTRE FOR MATERIALS FOR ELECTRONICS TECHNOLOGY (C-MET)
网页Dedicated to the furtherance of competent research and development in the firmament of Electronic Materials, the Centre for Materials for Electronics Technology (C-MET) functions as an autonomous scientific society under Ministry of Electronics & Information Technology (MeitY), Govt. of India.
实力靶点c-Met：奇峰陡起，再战江湖 - 知乎 - 知乎专栏
网页间质表皮转化因子 (c-Mesenchymal-epithelial transition factor, c-Met)是受体酪氨酸激酶的一种，较早就被发现在肿瘤细胞的活动中起到重要作用。. 这个蛋白对于肿瘤研究领域来说并不陌生，早在2008年，Nature Review Drug Discovery就发表过一篇关于c-Met抑制剂的详细综 …
“精准治疗”时代，c-Met为何能成为实力靶点？ - 搜狐
网页2022年5月12日 · 什么是c-Met？. 它的结构和功能有什么特点？. c-Met的全称为cellular-mesenchymal epithelial transition factor (细胞间质上皮转换因子)，为受体酪氨酸激酶家族成员，是一种多功能跨膜酪氨酸激酶，作为肝细胞生长因子 (hepatocvte growth factor，HGF)的受体。. 它主要在上皮细胞中 ...
c-MET靶点历久弥新：挑战者与被挑战者 - 界面新闻
网页C-MET，是一种在人体内由原癌基因编码的蛋白质，其能够和配体HGF（肝细胞生长因子）结合，激活PI3K/AKT、RAS/ERK/MAPK、Wnt/β-catenin等下游多条重要信号通路。 …
Structural basis of the activation of c-MET receptor - Nature
网页2021年7月1日 · The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal cell development and motility. Aberrant activation of c-MET can lead to both tumors growth and...
An overview of the c-MET signaling pathway - PMC - National …
网页c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.
靶点：c-Met - MedSci
网页2023年1月12日 · c-Met 为一种受体酪氨酸激酶，可通过与其配体肝细胞生长因子结合后，激活多种不同的细胞信号通路，包括有关增殖、运动、迁移及侵袭的细胞信号通路。. 研究表明，c-Met的异常激活可促进多种癌症的发展和进展,具体包括胃癌、肝癌、肺癌、结肠癌、乳腺 …
Soluble cMet levels in urine are a significant prognostic ... - Nature
网页2018年8月24日 · Hepatocyte growth factor and its receptor cMet activate biological pathways necessary for repair and regeneration following kidney injury. Here, we evaluated the clinical role of urinary cMet...
Progress of antibody-based inhibitors of the HGF–cMET axis
网页2017年3月24日 · The receptor tyrosine kinase cMET and its only known ligand, hepatocyte growth factor (HGF), play crucial roles in cellular proliferation, survival, invasion, tissue...
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