Clonality - an overview | ScienceDirect Topics
网页Clonality is a characteristic that describes how a population of cells, usually in culture, was derived. A clonal population is generated from a single cell, such as a stem cell, with the capacity for self-renewal. Clonality becomes very important when one asks what constitutes a cell line.
Clone (cell biology) - Wikipedia
网页A clone is a group of identical cells that share a common ancestry, meaning they are derived from the same cell. [1] Clonality implies the state of a cell or a substance being derived from one source or the other. Thus there are terms like polyclonal —derived from many clones; oligoclonal[2] —derived from a few clones; and monoclonal ...
T cell clonality assessment: past, present and future
网页T cell clonality testing has important clinical and research value, providing a specific and reproducible assessment of clonal diversity in T cell proliferations. Here we review the conceptual foundations of T cell clonality assays, including T cell ontogeny and T cell receptor structure and function; we also provide an introduction to T cell ...
Clonality assessment and detection of clonal diversity in classic ...
网页2021年12月3日 — Our data demonstrate improved performance of NGS-based detection of IG gene rearrangements in cHL whole-tissue specimens, providing a sensitive molecular diagnostic assay for clonality assessment...
The evolution of clonality testing in the diagnosis and monitoring …
网页In recent years, the development of new techniques for clonality detection has allowed researchers to better characterize, classify and monitor hematological neoplasms. In the past, clonality was primarily studied by performing Southern blotting analyses to characterize rearrangements in segments of the IG and TCR genes. Currently, the most ...
T cell clonality assessment: past, present and future - PubMed
网页T cell clonality testing has important clinical and research value, providing a specific and reproducible assessment of clonal diversity in T cell proliferations. Here we review the conceptual foundations of T cell clonality assays, including T cell ontogeny and T cell receptor structure and functio ….
Clonality in context: hematopoietic clones in their marrow …
网页2017年11月30日 — What maintains stable clonality in a patient with AA, and why are clones not more prone to further evolution in so many cases? How do somatic mutations relate to chromosome aneuploidy, so common among malignancies in general and after chemotherapy and with immune marrow failure, as well as in aging? 119 How does the immune system contribute to ...
EuroClonality/BIOMED-2 guidelines for interpretation and ... - Nature
网页2012年8月24日 — Here, we discuss important pre- and post-analytical aspects of clonality testing, provide guidelines for interpretation of clonality results and present a uniform way to report the results of...
Clonal architecture predicts clinical outcomes and drug …
网页2021年12月13日 — The impact of clonal heterogeneity on disease behavior or drug response in acute myeloid leukemia remains poorly understood. Using a cohort of 2,829 patients, we identify features of clonality ...
T 细胞组库分析及多样性和克隆性度量 - 简书
网页2021年12月12日 — 基于这一假设，作者提出了一种基于全局和局部 TCR 序列相似性的聚类算法，称为 GLIPH (通过胞旁热点对淋巴细胞相互作用进行分组,grouping of lymphocyte interactions by paratope hotspots) 根据共有 v 基因的丰富程度、 cdr3基因长度、克隆扩增、参与者之间 HLA 等位基因的共享 ...