Cytochrome P450 3A inhibitors and inducers - UpToDate
网页For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation.
Table of Substrates, Inhibitors and Inducers
网页2023年6月5日 · Table of Substrates, Inhibitors and Inducers (including: CYP Enzymes, Clinical index drugs, transporters, and examples of clinical substrates, inhibitors, and inducers).
CYP3A Inducers | FDA - U.S. Food and Drug Administration
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Inhibition and induction of CYP enzymes in humans: an update
网页2020年10月27日 · This review presents a comprehensive update on the inhibitors and inducers of the specific CYP enzymes in humans. The focus is on the more recent human in vitro and in vivo findings since the publication of our previous review on this topic in 2008.
Table 31.1, [CYP3A4 substrates, inhibitors and inducers...]. - The …
网页CYP3A4 substrates, inhibitors and inducers commonly used in HSCT (non-limitative list) (Flockhart 2018; Medicines Complete 2018) Bold font indicates strong inhibitors/inducers. a Alprazolam, diazepam, midazolam. b Amlodipine, diltiazem, verapamil. c Cyclosporine, tacrolimus, sirolimus. d Clarithromycin, erythromycin, NOT azithromycin.
The Role of CYP3A in Health and Disease - PMC - National Center …
网页2022年10月24日 · CYP3A5 is the main enzyme of the CYP3A subfamily in the lungs, and its induction in this organ, unlike in the liver, is triggered only by glucocorticoids (not by typical CYP3A inducers) [6,12]. In lung adenocarcinoma A549 cells, CYP3A5 is activated by glucocorticoids via a GR [ 9 ].
CYP3A - an overview | ScienceDirect Topics
网页CYP3A inducers include the glucocorticoids, rifampin, carbamazepine, phenobarbital, and phenytoin. Among the many significant CYP3A inhibitors are grapefruit juice, erythromycin, ketoconazole, clarithromycin, and verapamil.
Cytochrome P-450 CYP3A Inducers - DrugBank Online
网页Cytochrome P-450 CYP3A Inducers Accession Number DBCAT000492 (DBCAT004106) Description. Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP3A. Drugs
Cytochrome P450 Enzymes | Inducers & Inhibitors | Geeky Medics
网页2022年11月8日 · This article provides a summary of cytochrome P450 enzyme inducers and inhibitors as well as the relevance of genetic polymorphisms which influence metabolic pathways.
Drug Metabolism - The Importance of Cytochrome P450 3A4
网页Inducers of CYP3A4 include phenobarbital, phenytoin, rifampicin, St. John’s Wort and glucocorticoids. Cytochrome P450 enzymes are essential for the metabolism of many medicines and endogenous compounds. The CYP3A family is the most abundant subfamily of the CYP isoforms in the liver.