Basigin - Wikipedia
网页Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene. [5] [6] [7] This protein is a determinant for the Ok blood group system.
新冠靶点新视角四：跨膜糖蛋白CD147 - 知乎 - 知乎专栏
网页CD147，也称为basigin，Emmprin，是一种跨膜糖蛋白，Ig超家族的成员之一，被认为是细胞外基质金属蛋白酶（MMP）的有效诱导剂，能够诱导各种MMP的合成。 CD147分子及其与单抗E11F4之间的作用
新冠病毒感染的第二个关键蛋白——CD147 - 知乎
网页2020年11月9日 · CD147，又名Basigin或EMMPRIN，是一种跨膜糖蛋白，属于免疫球蛋白超家族。 CD147在多种肿瘤细胞和组织中高表达，通过诱导基质金属蛋白酶的分泌促进肿瘤浸润及转移。
The role of EMMPRIN in T cell biology and immunological diseases
网页2015年5月14日 · EMMPRIN is involved in T cell development, activation, proliferation, migration, invasion, adhesion, and energy metabolism. It is highly expressed in thymocytes during T cell development, playing a role in the transition phase from DN3 to DN4, where a proliferative burst occurs (A).
CD147在人类疾病中的生物学功能和临床应用：当前科学文献综述 …
网页CD147 或 EMMPRIN 是人类免疫球蛋白超家族的成员。 它在人类肿瘤中广泛表达，并通过刺激基质金属蛋白酶 (MMP) 和细胞因子的分泌在许多癌症的进展中发挥核心作用。 CD147 调节细胞增殖、凋亡和肿瘤细胞迁移、转移和分化，尤其是在缺氧条件下。 CD147 对许多器官系统也很重要。 本综述将详细概述 CD147 在人类生理和病理过程中的发现、表征、分子结构、多种生物学功能和调节机制。 特别是，最近的研究表明，CD147 不仅可以作为活化调 …
Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) …
网页2018年2月8日 · EMMPRIN is upregulated on monocytes during differentiation into macrophages, and an enhanced expression of EMMPRIN has been described in human atherosclerotic plaques, especially in macrophage-rich regions . In this review article, we systematically discuss the role of EMMPRIN and its interaction partners in …
新冠病毒入侵人体新靶点：跨膜糖蛋白CD147 - 知乎
网页CD147，也称为Basigin或EMMPRIN，是一种高度糖基化的单次跨膜蛋白，相对分子质量为50 kDa-60 kDa，属于免疫球蛋白超家族。 根据CD147来源不同，对其命名也有所不同，在人体内被称为basigin、白细胞活化相关M6抗原、肝癌细胞抗原Hab18G；在小鼠中被称为basigin或gp42；在大 ...
CD147/EMMPRIN overexpression and prognosis in cancer: A
网页2016年9月9日 · CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This...
EMMPRIN expression is associated with metastatic progression in ...
网页2021年9月26日 · Our data suggest that EMMPRIN acts as a mediator of osteosarcoma metastasis by regulating MMP and VEGF production in cancer cells as well as stromal cells. EMMPRIN could serve as a therapeutic target in osteosarcoma.
Emmprin (basigin/CD147): matrix metalloproteinase modulator …
网页Emmprin (basigin, CD147) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily. It is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases.
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