Insulin-like growth factor 1 receptor - Wikipedia
网页The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors.
IGF1R Gene - GeneCards | IGF1R Protein | IGF1R Antibody
网页2024年8月6日 · IGF1R (Insulin Like Growth Factor 1 Receptor) is a Protein Coding gene. Diseases associated with IGF1R include Insulin-Like Growth Factor I and Growth Delay Due To Insulin-Like Growth Factor I Resistance. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.
胰岛素样生长因子1受体 - 维基百科，自由的百科全书
网页胰岛素样生长因子1受体 （英語： insulin-like growth factor 1 receptor，IGF-1R）是人类 细胞 表面发现的 蛋白质，是激素 胰岛素样生长因子1 （IGF-1）的 细胞表面受体，属于 酪氨酸激酶 受体家族。 其高亲和力配体IGF-1，是一种在分子结构上与多肽类激素 胰岛素 类似的激素，在生长发育和成人的 合成代谢 中有重要作用，可引起 骨骼肌 或其他组织的 过度增殖。 此外，IGF-1R对 胰岛素 和IGF-2也有较低的亲和力 [7]。 完全缺失IGF-1受体的小鼠会在 …
Structural basis of the activation of type 1 insulin-like ... - Nature
网页2019年10月8日 · Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated...
IGF1R insulin like growth factor 1 receptor [ (human)]
网页IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic beta cells in gestational diabetes mellitus by upregulating ATG7. Exosomal miR-223 promotes ARDS by targeting insulin-like growth factor 1 …
The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic ...
网页2023年10月4日 · Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor (InsR).
IGF1R acts as a cancer-promoting factor in the tumor ... - Nature
网页2022年6月10日 · Herein we report increased amplification and mRNA expression, as well as increased protein expression (IGF1R/p-IGF1R) and IGF1R levels in tumor samples and serum from NSCLC patients,...
Mechanisms of Disease: signaling of the insulin-like growth
网页The IGF1 receptor (IGF1R) has been shown to be expressed in a wide range of tumors, and IGF1R signaling is crucial for tumor transformation and the survival of malignant cells. Several...
Understanding the tissue-specific roles of IGF1/IGF1R in regulating ...
网页Circulating IGF1 levels are reduced under fasting conditions and type 1 diabetes, associated with elevated GH levels. Given the healthy hepatocyte does not express appreciable levels of the IGF1R, the metabolic actions of IGF1 are …
The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic ...
网页2023年10月4日 · Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor ( …
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