Lysophosphatidic acid - Wikipedia
网页A lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule. [1][2][3][4] Function. LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPAR1, LPAR2, and LPAR3 (also known as EDG2, EDG4, and EDG7).
Role of lysophosphatidic acid and its receptors in health and …
网页2021年2月1日 · Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the...
Lysophosphatidic Acid - an overview | ScienceDirect Topics
网页Lysophosphatidic acid (LPA) is a simple lipid composed of a glycerol backbone connected to a phosphate head group, and it is commonly ester-linked to an acyl chain. LPA acts as a messenger both inside and outside cells, regulating various cellular responses such as proliferation, apoptosis, migration, and secretion.
Emerging roles of lysophospholipids in health and disease
网页2020年11月1日 · Revealing how circulating lysophospholipids are produced, released, transported, and utilized in multi-organ systems is critical to understand their functions. The discovery of enzymes, carriers, transporters, and membrane receptors for these lysophospholipids has shed light on their physiological significance.
Lysophosphatidic Acid Receptors: Biochemical and Clinical …
网页2020年3月15日 · Lysophosphatidic acid (LPA) is essential for brain development and nervous system function, signaling through six different G-protein coupled receptors (LPAR1-6). The role of LPA receptors in the nervous system is one of …
Lysophosphatidic acid, a simple phospholipid with myriad functions
网页2023年6月1日 · Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group, glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA plays an important role as an essential bioactive signaling molecule via its specific six G protein-coupled receptors, …
Molecular mechanism of lysophosphatidic acid-induced …
网页2019年2月25日 · Lysophosphatidic acid (LPA) is a blood-derived bioactive lipid with numerous biological activities exerted mainly through six defined G protein-coupled receptors (LPA 1 -LPA 6). LPA was first...
The role of lysophosphatidic acid in the physiology and ... - PubMed
网页2019年3月1日 · Lysophosphatidic acid (LPA) is the simplest phospholipid found in nature. LPA is mainly biosynthesized in tissues and cells by autotoxin and PA-PLA1α/PA-PLA1β and is degraded by lipid phosphate phosphatases (LPPs). It is an important component of biofilm, an extracellular signal transmitter and intr ….
Lysophosphatidic acid (LPA) receptors: signaling properties and …
网页Lysophosphatidic acid (LPA), once thought to be an inert metabolite in the biosynthesis of membrane phospholipids, is now well-recognized as an important signaling molecule. Acting through G protein-coupled receptors (GPCRs), LPA alters many different cellular responses, such as proliferation, survival, cytoskeletal changes, calcium influx and ...
Lysophospholipid Mediators in Health and Disease - PubMed
网页2022年1月24日 · Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are produced by the metabolism and perturbation of biological membranes. Both molecules are established extracellular lipid mediators that signal via specific G protein-coupled receptors in vertebrates.