MMP2 - Wikipedia
网页72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. [5] The MMP2 gene is located on chromosome 16 at position 12.2.
MMP2 Gene - GeneCards | MMP2 Protein | MMP2 Antibody
网页2024年8月6日 · MMP2 (Matrix Metallopeptidase 2) is a Protein Coding gene. Diseases associated with MMP2 include Multicentric Osteolysis, Nodulosis, And Arthropathy and Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum. Among its related pathways are Matrix metalloproteinases and Nervous system development.
基质金属蛋白酶（MMPs）种类及功能 - 知乎 - 知乎专栏
网页基质金属蛋白酶（MMPs），1962年首先被确定为一种胶原蛋白水解酶，在蝌蚪尾巴的吸收过程中导致ECM蛋白降解。. 属于metzincins超家族，是一类锌依赖性内肽酶，可降解ECM的各种蛋白质组分。. (一) MMP家族结构特点. 在脊椎动物中，MMP家族由28个成员组成，至 …
The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in …
网页2020年5月5日 · MMP-2 (a type of gelatinase A, 72 kDa) and MMP-9 (a type of gelatinase B, 92 kDa) are composed of 3 domains, distinguished by the presence of type II additional fibronectin domain inserted into the catalytic domain.
MMP2 gene - MedlinePlus
网页The MMP2 gene provides instructions for making an enzyme called matrix metallopeptidase 2. This enzyme is produced in cells throughout the body and becomes part of the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells.
Matrix Metalloproteinase 2 (MMP2) - SpringerLink
网页2016年3月11日 · MMP2 can regulate pathological growth in vasculature and plays a role in angiogenesis of variety of diseases by releasing angiogenic factors and assisting in cell migration and cell adhesion. Further, MMP-2 can be a potential cause in initial tumor formation by altering ECM, which provides optimal environment for tumor growth.
MMP-2: A modulator of neuronal precursor activity and
网页2017年8月30日 · Matrix Metalloproteinase2, (MMP2, gelatinase A) is a zinc-containing enzyme with a broad substrate specificity including components of the extracellular matrix, cell surface molecules and a wide range bioactive molecules. MMP2 is known to play important roles in a variety of signaling pathways and p ….
Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular …
网页2022年8月23日 · Similar to MT1-MMP, MMP-2 localizes to the caveolae, mitochondria, cytoskeleton, nucleus and nucleolus and functions in calcium regulation, contractile dysfunction, gene expression and ribosomal RNA transcription.
Assigning matrix metalloproteinase roles in ischaemic cardiac
网页2018年5月11日 · Matrix metalloproteinases (MMPs) are a family of 25 enzymes that proteolytically process both ECM and inflammatory proteins, making MMPs highly relevant to cardiac remodelling after MI 6, 7. Each...
MMP2 matrix metallopeptidase 2 [ (human)] - National Center for ...
网页Inactivating mutations in MMP-2 cause Winchester syndrome, a multicentric osteolysis syndrome. This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction.
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