CYP3A4 - Wikipedia
网页Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.
What are some common medications classified as weak, moderate …
网页Of the CYP enzymes, CYP3A4 is not only the most prevalent CYP enzyme in the liver, but is used by more than 50% of medications on the market for their metabolism and elimination from the body. Weak inhibitors of CYP3A4 include: cimetidine. Moderate inhibitors of CYP3A4 include: amiodarone, erythromycin, fluconazole, miconazole, diltiazem ...
Cytochrome P450 3A inhibitors and inducers - UpToDate
网页Cytochrome P450 3A (including 3A4) inhibitors and inducers. For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation. These classifications are based upon US ...
细胞色素P450 3A4代谢机制有关方面的研究进展 - 搜狐
网页2017年9月11日 — 细胞色素P450 (CYP450)酶是一组参与内源性化合物 (如胆汁酸、前列腺素甾体类激素、脂肪酸等)和外源性化合物 (药物、致癌物、毒物前致突变物)生物转化的混合功能氧化酶,存在于所有的生物体中。. 目前,已发现超过270种的CYP450家族和12 000种个体基因型。. 原核生物 ...
Cytochrome P-450 CYP3A4 Inducers - DrugBank Online
网页An antibiotic used to treat mycobacterium avium complex disease in patients with HIV. An antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.
UNDERSTANDING THE MECHANISM OF CYTOCHROME P450 3A4: …
网页2013年3月3日 — CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen. Among 57 human P450s, the 3A4 isoform (CYP3A4) is the most abundant and the most important because it metabolizes the majority of the administered drugs.
CYP3A4 - an overview | ScienceDirect Topics
网页CYP3A4 is the primary hepatic CYP expressed postnatally. It accounts for approximately 30% of the total P450 content in the liver and intestine,42 and is the primary enzyme involved in catalyzing the biotransformation of over 75 commonly used therapeutic drugs.
CYP3A4 cytochrome P450 family 3 subfamily A member 4 [ (human)]
网页The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents.
Understanding the mechanism of cytochrome P450 3A4
网页CYPs share a common protein fold but differ in substrate selectivity and catalyze a wide variety of monooxygenation reactions via activation of molecular oxygen. Among 57 human P450s, the 3A4 isoform (CYP3A4) is the most abundant and the most important because it metabolizes the majority of administered drugs.
Cytochrome P-450 CYP3A4 Inhibitors (weak) - DrugBank Online
网页An antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-positive breast cancer in patients who received prior chemotherapeutic treatments. A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.