[Construction and expression of regulatable recombinant …
网页The regulatable recombinant adenovirus vector for mouse PLP-Ig was constructed and expressed successfully, which lays the foundation for further study on gene therapy of EAE and induction of immune tolerance.
PLP peptide expression on Ig-PLP1 and Ig-PLP-LR. Rabbit …
网页Ig-proteolipid protein (PLP) 1 and Ig-myelin oligodendrocyte glycoprotein (MOG) are Ig chimeras carrying the encephalitogenic PLP 139-151 and MOG 35-55 amino acid sequence,...
Presentation of a T Cell Receptor Antagonist Peptide by …
网页1997年3月3日 · Using an efficient endocytic presentation system, we demonstrate that a proteolipid protein (PLP) TCR antagonist peptide (PLP-LR) presented on an Ig molecule (IgPLP-LR) abrogates the activation of T cells stimulated with free encephalitogenic PLP peptide (PLP1), native PLP, or an Ig containing PLP1 peptide (Ig-PLP1).
PLP peptide expression on Ig-PLP1 and Ig-PLP-LR. Rabbit …
网页In prior studies, we demonstrated that an immunoglobulin (Ig) chimera carrying the encephalitogenic proteolipid protein (PLP)1 peptide corresponding to amino acid sequence 139-151 of PLP,...
聚焦离子束扫描电子显微镜将病理性髓鞘外翻与缺乏 Plp1 或 Mag
网页CNS 髓鞘的超微结构需要专门的结构髓鞘蛋白，包括跨膜四跨蛋白脂质蛋白 (PLP) 和 Ig-CAM 髓鞘相关糖蛋白 (MAG)。 为了更好地理解它们的功能相关性，我们询问了如果缺乏 PLP 或 MAG，轴突/髓鞘单位在多大程度上显示出相似的形态变化。 因此，我们使用聚焦离子束扫描电子显微镜 (FIB-SEM) 并排重新研究Plp和Mag中的轴突/髓磷脂单元-无效突变小鼠。 通过三维重建和形态测量分析，病理性髓鞘外翻在两种模型中沿着有髓轴突纵向延伸 …
Effective amelioration of EAE by agg Ig-PLP1. (a) Groups
网页In previous studies we have shown that Ig-PLP1, expressing the H-2 s restricted proteolipid protein (PLP) peptide 139-151, is able to suppress relapses of PLP1-induced EAE (Legge et al., 2000...
Multi-Modal Antigen Specific Therapy for Autoimmunity
网页2009年7月10日 · As Ig-PLP1 is more potent than Ig-PLP-LR in the down-regulation of T cells, we conclude that peptide affinity plays a critical role in this multi-modal approach of T cell modulation. Key Words: Peripheral tolerance T cell antagonist Bystander suppression
Multi-modal antigen specific therapy for autoimmunity
网页Consequently, IL-10 displays bystander suppression and synergizes with presentation without costimulation to drive effective modulation of EAE. As Ig-PLP1 is more potent than Ig-PLP-LR in the down-regulation of T cells, we conclude that peptide affinity plays a critical role in this multi-modal approach of T cell modulation.
Correlation Between Anti-Myelin Proteolipid Protein (PLP) …
网页2020年8月21日 · The anti-PLP 181−230 antibody levels were significantly different in RR-MS patients and CIS patients compared to both healthy individuals and OND patients, whereas the SP-MS patient antibody levels were only significantly different to healthy individuals, and PP-MS patient antibody levels were …
Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of …
网页2020年8月13日 · In this review, we put forward the hypothesis that pyridoxal 5′-phosphate (PLP)-dependent enzymes, which regulate multiple pathways of Trp metabolism in both the host and in microbes, might represent critical nodes and that modulating the levels of vitamin B6, from which PLP is derived, might represent a …