RUNX2 - Wikipedia
网页Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation .
Runt-related transcription factor 2（RUNX2） - Abcam中文官网
网页runx2是转录因子 runx 家族的一员，参与成骨细胞分化和骨骼形态发生过程。 RUNX2对于成骨细胞的成熟，以及膜内和软骨内的骨化至关重要。 RUNX2可以通结合启动子或增强子的核心位点来调节骨钙蛋白、骨唾液蛋白和T细胞受体增强子等不同基因的转录。
RUNX2 Gene - GeneCards | RUNX2 Protein | RUNX2 Antibody
网页2024年8月6日 · This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.
RUNX2 RUNX family transcription factor 2 [ (human)]
网页2024年8月27日 · This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.
Runt相关转录因子2基因在骨骼发育及间充质干细胞分化中的作用 …
网页Runt相关转录因子2(Runx2)作为一种细胞分化重要的转录因子，能够调控众多基因的转录。Runx2不仅调控成骨细胞的分化、成熟和功能，还可以促进软骨细胞的增殖肥大，对于骨骼系统发育有重要的意义 。不仅如此，Runx2还是调控体外间充质干细胞分化的靶基因 ...
Whole Aspect of Runx2 Functions in Skeletal Development
网页2022年5月21日 · Runx2 enhances the proliferation of osteoblast progenitors and induces their commitment to osteoblast lineage cells through the direct regulation of the expressions of a hedgehog, fibroblast growth factor (Fgf), Wnt, and parathyroid hormone-like hormone (Pthlh) signaling pathway genes and distal-less homeobox 5 (Dlx5), which all …
Runx2: A master organizer of gene transcription in developing and ...
网页2005年9月26日 · Runx2 is an organizing hub for gene expression. Runx2 binds a specific DNA sequence to regulate gene transcription and is localized to discrete subcellular foci by the nuclear matrix. Runx2 interacts with CBFβ, as well as other proteins that are classified as corepressors, coactivators, or transcription factors.
Molecular Mechanism of Runx2-Dependent Bone Development
网页2020年2月2日 · Runx2 is an essential transcription factor for skeletal development. It is expressed in multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a major role in chondrocyte maturation, and Runx3 is partly involved. Runx2 regulates chondrocyte proliferation by directly regulating …
Runx2: Structure, function, and phosphorylation in osteoblast ...
网页Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events ….
RUNX2 gene - MedlinePlus
网页The RUNX2 gene provides instructions for making a protein that is involved in the development and maintenance of the teeth, bones, and cartilage. Learn about this gene and related health conditions.
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