Toll-like receptor 4 - Wikipedia
网页Toll-like receptor 4 (TLR4), also designated as CD284 (cluster of differentiation 284), is a key activator of the innate immune response and plays a central role in the fight against bacterial infections. TLR4 is a transmembrane protein of approximately 95 kDa that is encoded by the TLR4 gene.
Toll样受体 - 百度百科
网页Toll样受体（Toll-like receptors, TLR）是参与非特异性免疫（天然免疫）的一类重要蛋白质分子，也是连接非特异性免疫和特异性免疫的桥梁。TLR是单个的跨膜非催化性蛋白质，可以识别来源于微生物的具有保守结构的分子。
TLR4——细菌LPS的受体 - 知乎 - 知乎专栏
网页TLR4——细菌LPS的受体. Toll 样受体 4（Toll-like receptor 4，TLR4）是由 Poltorak 等于 1998 年发现的 一种 I 型跨膜蛋白，其由 TLR4 基因编码，并表达于包括单核细胞，巨嗜细胞在内 的多种组织细胞中，可以识别革兰氏阴性细菌的脂多糖（lipopolysaccharide，LPS）， …
Toll-like receptor 4 (TLR4): new insight immune and aging
网页2023年11月24日 · TLR4, a receptor with a central role in innate immune signaling, orchestrates inflammatory responses by modulating the activity of transcription factors. Recent research has unveiled the significance of regulating TLR4 activity and expression in the context of age-related diseases.
TLR-4® | Compact Tactical Light with Laser - Streamlight
网页Lightweight rail-mounted light with red laser, constructed of an impact-resistant polymer, designed to fit compact and sub-compact handguns. It also fits most full-sized handguns with rails on the market.
Targeting Toll-like receptor-4 (TLR4) – emerging therapeutic …
网页Procedures blocking TLR functionality have shown pronounced effects on pain behavior otherwise observed in models of chronic inflammation and nerve injury. This review addresses the role of TLR4 as an emerging therapeutic target for the evolution of persistent pain and its role in non canonical signaling mediating anomalous proalgesic actions ...
TLR4 - 维基百科，自由的百科全书
网页Toll样受体4 （英語： Toll-like receptor 4）是由人类 基因 TLR4 编码的 蛋白质，是一种 膜蛋白质，也被称为 CD284 （分化簇 284，cluster of differentiation 284），是 模式识别受体 中 Toll样受体 （TLR）家族的成员，可结合其配体 脂多糖 （LPS）激活 NF-κB 信号通路，在 先天免疫系統 中起到重要作用 [6]。 参考文献. ^ 對toll like receptor 4起作用的藥物；在維基數據上查看/編輯參考. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000136869 - …
The Role of Toll-Like Receptor 4 in Infectious and Noninfectious ...
网页2016年5月18日 · Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections.
TLR4 signalling - Nature Reviews Immunology
网页Toll-like receptor 4 (TLR4) is unique among TLRs in its ability to activate two distinct signalling pathways — one pathway is activated by the adaptors TIRAP...
Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and …
网页2021年9月12日 · Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity.