Malonyl-CoA - Wikipedia
网页Malonyl-CoA is a coenzyme A derivative of malonic acid. Functions. It plays a key role in chain elongation in fatty acid biosynthesis and polyketide biosynthesis. Cytosolic fatty acid biosynthesis. Malonyl-CoA provides 2-carbon units to fatty acids and commits them to fatty acid chain synthesis.
丙二酰辅酶A - 百度百科
网页丙二酰辅酶A（英语：Malonyl-CoA，或称为 丙二酸 单酰 辅酶A）是一种辅酶A的衍生物。 化合物作用. 播报. 编辑. 该化合物在脂肪酸的生物合成的延伸阶段以及 聚酮 化合物的生物合成中起到重要作用。 丙二酰辅酶A同时也被用于使 α-酮戊二酸 跨过 线粒体膜 转运到 线粒体基质 中。 脂肪酸合成. 播报. 编辑. 在脂肪酸合成中，它为脂肪酸提供二碳单位，将二碳单位加到延长中的脂肪酸 碳链 中。 丙二酰A是在 乙酰辅酶A羧化酶 的作用下使 乙酰辅酶A 羧 …
丙二酰辅酶A - 维基百科，自由的百科全书
网页丙二酰辅酶A （英語： Malonyl-CoA，或称为 丙二酸单酰辅酶A）是一种 辅酶A 的衍生物。 作用. 该化合物在 脂肪酸 的生物合成的延伸阶段以及 聚酮化合物 的生物合成中起到重要作用。 丙二酰辅酶A同时也被用于使 α-酮戊二酸 跨过线粒体膜转运到线粒体基质中。 脂肪酸的生物合成. 在脂肪酸合成中，它为脂肪酸提供二碳单位，将二碳单位加到延长中的脂肪酸碳链中。 丙二酰A是在 乙酰辅酶A羧化酶 的作用下使 乙酰辅酶A 羧化而形成的。 一分子乙酰辅 …
Malonic acid - Wikipedia
网页Malonic acid is a dicarboxylic acid with structure CH 2 (COOH) 2. The ionized form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acid's diethyl ester. The name originates from the Greek word μᾶλον (malon) meaning 'apple'.
Malonyl-CoA - an overview | ScienceDirect Topics
网页Malonyl-CoA is a central metabolite in fatty acid biochemistry. It is the rate-determining intermediate in fatty acid synthesis but is also an allosteric inhibitor of the rate-setting step in mitochondrial long-chain fatty acid oxidation.
Acetyl-CoA-independent malonyl-CoA biosynthesis - Nature
网页2024年4月26日 · Malonyl-CoA is one of the fundamental building blocks for the synthesis of industrially or pharmaceutically important chemicals, but its biosynthesis via the innate acetyl-CoA...
Malonyl-CoA links lipid metabolism to nutrient signalling by …
网页2023年8月10日 · We discovered that accumulation of malonyl-CoA — the intermediate metabolite produced by ACC1 and consumed by FAS — inhibited mTORC1 (but not mTORC2) kinase activity and downregulated other ...
malonyl-CoA | C24H38N7O19P3S | CID 644066 - PubChem
网页Malonyl-CoA is the S-malonyl derivative of coenzyme A. It has a role as an EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor, a metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a coenzyme A. It is a conjugate acid of a malonyl-CoA(5-).
Malonyl-CoA: the regulator of fatty acid synthesis and oxidation
网页2012年6月1日 · Regulation of malonyl-CoA determines the switch between fatty acid synthesis and oxidation. Adapted with permission from the Annals of the New York Academy of Sciences .
Malonyl-CoA is a conserved endogenous ATP-competitive …
网页2023年8月10日 · In summary, our data reveal that Mal-CoA is a direct and ATP-competitive inhibitor of mTORC1 in both yeast and human cells, thus serving as a key metabolite that directly connects the cellular FA...
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