Preneoplastic stromal cells promote BRCA1 -mediated breast
网页2023年3月13日 · Using single-cell RNA sequencing analysis of human preneoplastic BRCA1+/mut and noncarrier breast tissues, we show distinct changes in epithelial homeostasis including increased proliferation and...
Preneoplastic Lesions - SpringerLink
网页The development of primary tumors is often preceded, both in humans and experimental animals (mainly rodents), by the appearance of lesions referred to as preneoplastic. These consist of genetically and phenotypically altered cells exhibiting a higher risk of malignant evolution than normal cells.
Preneoplastic cells switch to Warburg metabolism from their …
网页2024年1月25日 · We set out to investigate energy metabolism in the HRAS G12V driven preneoplastic cell (PNC) at inception, in a zebrafish skin
Computational Identification of Preneoplastic Cells Displaying …
网页2022年7月18日 · This study develops a computational strategy to dissect the heterogeneity of differentiation states within a preneoplastic cell population, allowing identification of stem-like cells that may drive cancer progression.
A single-cell RNA expression atlas of normal, preneoplastic and ...
网页2021年6月1日 · The transcriptomes of preneoplastic BRCA1 +/-tissue versus tumors highlighted global changes in the immune microenvironment. Within the tumor immune landscape, proliferative CD8 + T cells characterized triple-negative and HER2 + cancers but not ER + tumors, while all subtypes comprised …
Metabolic Alterations in Preneoplastic Development Revealed by ...
网页2021年8月3日 · Our analysis of these very early stage preneoplastic tissues identified metabolic alterations in pyrimidine, purine and amino acid metabolism, which are changes often reported in cancers. This work establishes a proof of principle for using the zebrafish larval skin model to assess metabolic re-programming induced by oncogene activation in …
Immune evolution from preneoplasia to invasive lung ... - Nature
网页2021年5月11日 · In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluorescence ...
网页2021年5月5日 · preneoplastic BRCA1+/ tissue (28 specimens), and tumors (34 spec-imens) representing estrogen receptor (ER) +, HER2 , and triple-negative (TNBC) breast cancers, including male tumors and seven matched pairs of ER+ tumors and involved lymph nodes. Not surprisingly, extensive changes in the immune/stromal landscape
EMBO J：新型细胞图谱或能帮助绘制出人类健康和癌变的乳腺组织 …
网页2021年5月16日 · 单细胞RNA测序技术是一项新技术，其彻底改变了科学家们研究诸如乳腺组织等人类复杂组织的方式； 而且生物信息学对于获取研究人员所研究的不同乳腺组织中不同细胞群体的全局视图至关重要；计算方法能帮助研究人员以前所未有的分辨率来检测乳腺组织中不同细胞的基因表达模式和差异。 综上， 本文研究中所开发出的RNA图谱是迄今为止关于人类乳腺组织的最全面图谱，其能提供科学家们理解其中所包含的不同细胞类型的框 …
Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive …
网页2021年9月14日 · In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process. Keywords: gastric carcinoma, pre-neoplastic lesions, gastric carcinogenesis, biomarkers, pathology. Go to: 1. Introduction.
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