Many of these drugs are metabolized by cytochrome P450 3A4 (CYP3A4), which has been estimated to be involved in the metabolism of ∼50% of prescription drugs and is therefore a common cause of ...

As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of being broken down as usual, more of the drug enters ...

Clopidrogel must be metabolized in the liver by CYP2C19 (CYP3A4) to its active form. The antiplatelet effect of clopidrogel varies among patients. Poor metabolizers of the drug do not effectively ...

The drug is cleared by cytochrome P450 (CYP ... Blood levels of eplerenone are increased by inhibitors of CYP3A4, such as ketoconazole and saquinavir. About 50% is bound by plasma protein.

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

If you have a higher A1C or if metformin alone is not enough to meet your A1C and blood sugar goals, your doctor may prescribe a combination of medications. Each type of diabetes medication can ...

Members of my lab are interested in how hormones act in the brain to influence response to drugs of abuse. This student was engaged in primarily archival research on this topic. During her time ...

FDA drug alerts in pulmonology, including drug approvals/warnings, vaccine approvals, medical device recalls/updates, and ...

ROCKVILLE, Md. & EDMONTON, Alberta-- ( BUSINESS WIRE )--Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced that the Japanese Ministry of Health, Labour, and Welfare ...

Exelixis, Inc. (Nasdaq: EXEL) today announced updated and final data from CABINET, a phase 3 pivotal trial evaluating ...

What Are Ulcerative Colitis Medications? Ulcerative colitis (UC) medications are drugs that help you manage the symptoms and progression of ulcerative colitis. Because UC affects your autoimmune ...

The government reported last month that illegal and dangerous drug use increased in the United States. Again. But it didn’t just increase. For the third year in a row, it increased above and ...