As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of being broken down as usual, more of the drug enters ...

The drug is cleared by cytochrome P450 (CYP ... Blood levels of eplerenone are increased by inhibitors of CYP3A4, such as ketoconazole and saquinavir. About 50% is bound by plasma protein.

Clopidrogel must be metabolized in the liver by CYP2C19 (CYP3A4) to its active form. The antiplatelet effect of clopidrogel varies among patients. Poor metabolizers of the drug do not effectively ...

This is because grapefruit juice interacts with an enzyme in the intestines called cytochrome P450 3A4 (CYP3A4), which is responsible for breaking down many different types of drugs. Compounds ...

FDA drug alerts in pulmonology, including drug approvals/warnings, vaccine approvals, medical device recalls/updates, and ...

If you have a higher A1C or if metformin alone is not enough to meet your A1C and blood sugar goals, your doctor may prescribe a combination of medications. Each type of diabetes medication can ...

Members of my lab are interested in how hormones act in the brain to influence response to drugs of abuse. This student was engaged in primarily archival research on this topic. During her time ...

Could Taking Certain Drugs Reduce Risk of Ruptured Brain Aneurysm? June 5, 2024 — A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

Exelixis, Inc. (Nasdaq: EXEL) today announced updated and final data from CABINET, a phase 3 pivotal trial evaluating ...

This week, The National and The War On Drugs commence a 19-date nationwide run of shows. It has been dubbed The Zen Diagram Tour, and I can only assume that the title refers to the commonly held ...

The government reported last month that illegal and dangerous drug use increased in the United States. Again. But it didn’t just increase. For the third year in a row, it increased above and ...