Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

Hot Spot. GWAS of tau PET scans found a single locus where SNPs (circles) were associated with higher tangle loads. The strongest signal came from SNP rs2113389 (gray diamond). [Courtesy of Nho et al.

Despite knowing that the active centres of many metalloprotein enzymes are iron porphyrin ... can mimic the activity of various types of cytochrome P450. Can the catalytic activity and reaction ...

Austocystin D promotes cell death by damaging their DNA, a process which might be dependent on cytochrome P450 (CYP) oxygenase enzymes. Notably, austocystin D has shown significant activity ...

The primary molecular defect underlying the majority of PCG cases has been identified as mutations in the cytochrome P4501B1 (CYP1B1) gene. This gene is expressed in tissues of the anterior ...

Learn what distinguishes common blood pressure medicines amlodipine and lisinopril, and how to know which one is best for you ...

Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6). Tamoxifen is a substrate for ATP-binding cassette transporter ...

One key enzyme is cytochrome P450 3A4, or CYP3A4. As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of ...

Research shows that St. John’s wort works as well as some antidepressants for the short-term treatment of depression. Be ...

For example, there are genetic variations in enzymes referred to as cytochrome P450 (CYP450) enzymes that play a crucial role ...

They used three different engineered P450 enzymes to carry out selective C–H oxidations and epoxidations. Fasan says those enzymatic transformations provided a “springboard” to additional ...

Comparative metabolism of furan in rodent and human cryopreserved hepatocytes. Drug Metabolism and Disposition, 42: 1132-6. Gates LA, Lu D, & Peterson LA (2012). Trapping of cis-2-butene-1,4-dial to ...