Secondary efficacy analyses of the pivotal SEQUOIA-HCM trial continued to favor aficamten, supporting a potential role for ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for ...

Possible interactions of omeprazole with other benzodiazepines that are metabolized by the cytochrome P450 system should ... effect of PPIs through CYP2C19. Inhibition of CYP2C19-dependent ...

Many of these drugs are metabolized by cytochrome P450 3A4 (CYP3A4), which has been ... caused several cases of rhabdomyolysis 4, is an inhibitor of transporters such as P-glycoprotein, as well ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

Evidence suggests potential interactions between ART and some antipsychotic agents. Cytochrome P450 inhibitors have the potential to increase the concentration of clozaril and pimozide ...

Concomitant use of CAMZYOS with certain cytochrome P450 inhibitors or discontinuation of certain cytochrome P450 inducers may increase the risk of heart failure due to systolic dysfunction ...

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of cytochrome P450 epoxygenase that have potent anti-inflammatory activity. In collaboration with Dr. Zheng’s group at Baylor, we ...

Revatio and Viagra are broken down by an enzyme called cytochrome p450 (CYP450). If Revatio or Viagra are combined with a CYP ...

Initiate appropriate therapy if these effects occur as needed. Drug Interactions with Strong Cytochrome P450 3A4 Inhibitors Use caution when considering the coadministration of Breztri Aerosphere ...

p38 MAP Kinase regulates inflammation and is a major target for drug development for conditions including autoimmune diseases, myocardial ischemia, and cancer. Existing inhibitors of p38 have failed ...

Concurrent administration of fluticasone propionate and strong cytochrome P450 3A4 inhibitors (eg, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir ...