ATX is a key enzyme involved in the generation of lysophosphatidic acid, a lipid implicated in a variety of fibrotic diseases that affect the liver, lung, kidney and skin. ATX inhibitors have the ...
Toby Maher, MD, PhD, professor of clinical medicine, Keck Medicine of USC, discusses recent advancements in clinical trials for patients with idiopathic pulmonary fibrosis (IPF) and progressive ...
an "oral small molecule antagonist that targets the lysophosphatidic acid 1 receptor ("LPA1R")", is in Phase 1 studies for IPF already. In general, I would say the market is somewhat skeptical of ...
into a signalling molecule known as lysophosphatidic acid (LPA). These signals can induce various responses along multiple cellular signalling pathways that lead to a build up of fibroblasts.
Biochem J. 2007 Oct 15;407(2):243-54. PubMed PMID: 17617061. Khurana S, Tomar A, George SP, Wang Y, Siddiqui MR, Guo H, Tigyi G, Mathew S. Autotaxin and lysophosphatidic acid stimulate intestinal cell ...
Autotaxin is a protein of approximately 900 amino acids discovered in the early 1990s and is an important enzyme for generating the lipid-signaling molecule, lysophosphatidic acid. Bridge was ...
Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling. Commun Biol. 2021 Jun 24;4(1):780. doi: 10.1038/s42003-021-02308-6.