Researchers have found that odanacatib (ODN), a cathepsin K (CatK) inhibitor, is an effective and safe treatment option for ...

Another new target is cathepsin K, a cysteine protease that is abundantly expressed in osteoclasts. Odanacatib (Merck), the most advanced compound in this class, is currently in Phase III studies ...

We found that MOD06051 works as a selective inhibitor for Cathepsin C (CatC), a key regulator that activates multiple enzymes ...

Researchers from the National Center for Nanoscience and Technology and Chongqing Medical University developed three types of nanostructures that combine L-phenylalanine with metal ions. This ...

PubMed PMID: 28710749; PubMed Central PMCID: PMC5654643. View publication. Minchew CL, Didenko VV. Dual Detection of Nucleolytic and Proteolytic Markers of Lysosomal Cell Death: DNase II-Type Breaks ...

In the chemical world, the tiny hyphen in antibody-drug conjugates—or ADCs, as they’re commonly known—does a lot more work ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

In addition, the researchers found that the uptake of nanostructures by DCs may induce the release of cathepsin B, which, along with the outflow of potassium ions, activates the inflammasome ...

TNX-4200 (orally available CD45 antagonist), TNX-3900 (cathepsin inhibitor), TNX-4000 (glycan-targeted biologic) Tonix is developing potential broad-spectrum antiviral drugs in three programs ...

Clinical and Radiographic Outcomes of Four Different Treatment Strategies in Patients With Early Rheumatoid Arthritis (the Best Study): A Randomized, Controlled Trialfrom Arthritis & Rheumatism ...

Osteoarthritis (OA) is the most common arthritis worldwide, causing pain, disability, and loss of function due to chronic joint ...