Investigators suggest that further research could help discover potential therapeutic approaches that leverage the alternative splicing-nonsense-mediated decay process.
Dr. Fuqua was the first to discover alternatively spliced transcriptional isoforms and somatic mutations in breast tumors. Recently mutations in ER have been rediscovered by a number of laboratories ...
The authors present a valuable study exploring the interaction between JNK signaling and high sucrose feeding. The strength of evidence supporting these observations is solid, including multi-tissue ...
This manuscript describes the impact of modulating signaling by a key regulatory enzyme, Dual Leucine Zipper Kinase (DLK), on hippocampal neurons. The results are interesting and will be important for ...