One of the leading explanations for why is that the genetic mutations that favour reproducing earlier in life could also ...

Sepsis mortality, including a 28-day mortality, is associated with a genetic predisposition to gastroesophageal reflux disease.

The recent advances in high-throughput sequencing studies, integrated with findings derived from multimodal brain imaging data analyses and genome-wide association studies (GWAS) have expanded our ...

"We confirm a hypothesis called the antagonistic pleiotropy hypothesis, which says that mutations promoting reproduction are ...

This model illustrates how alleles of modifier and modified genes affect penetrance, dominance modification, expressivity and pleiotropy, and modulate the phenotypes of mutant organisms.

A particular interest is in identifying pleiotropy (when a single gene influences two or more seemingly unrelated physical traits) and environmental modifiers of genetic associations, including ...

A study reveals loneliness correlates with 13 illness categories, highlighting its role as a potential proxy marker rather ...

A large-scale genetic study involving over 1 million participants has uncovered more than 100 genes associated with anxiety.

The following is a summary of “Causal relationships between gut microbiome and aplastic anemia: a Mendelian randomization ...

In a sensitivity analysis, none of the single-nucleotide polymorphisms were detected as heterogeneous and no significant pleiotropy was observed. "The analysis suggests that dietary intake of ...

MR-Base enables automation of two-sample MR using 11 MR methods (including MRC-IEU methods addressing pleiotropy). We are working with various pharmaceutical companies on approaches to prioritise drug ...