The RNA world hypothesis implies that coded protein synthesis evolved from a set of ribozyme catalyzed acyl-transfer reactions, including those of aminoacyl-tRNA synthetase ribozymes. We report ...

So far, this RNA system, called a ribozyme, has only copied a short stretch of itself, but further work could lead to systems that completely self-replicate. If it couldn't adapt to changing ...

RNA transcripts containing the hammerhead ribozyme have been engineered to self-destruct in the presence of specific nucleoside 3′,5′-cyclic monophosphate compounds. These RNA molecular ...

This article discusses the journeys of three gene therapy startups in South Korea, Japan, and China, and the products they ...

A major focus of our lab is to harness the power of small catalytic RNAs (such as the hammerhead ribozyme) to create new RNA switches that can be turned on or off by small molecules. One of the ...

Curr. Opin. Chem. Biol. 41, 71-83. The crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme has been solved as part of a collaborative effort championed ...

These results demonstrated that the ribosome is a ribozyme. Since 2000 Nenad Ban is a professor of structural molecular biology at the ETH Zurich (Swiss Federal Institute of Technology). Structural ...

At the Korean Innovative Startup Awards, six startups were recognized for advancements in chip design, batteries, aerospace, ...

FIGURE 1. Location of genomic and antigenomic ribozyme sequences, and the predicted ORF of the delta ... [+] antigen in the avian HDV-like genome compared to their location in the HDV genome sequence.

Two major areas of interest are: New catalytic activities for DNA and RNA, and control of ribozyme activity Recently, it has been established that specific DNA sequences are capable of catalyzing a ...

Kannan, K, C. Coarfa, P-W Chao, L. Luo, Y. Wang, A. E. Brinegar, S. Hawkins, A. Milosavljevic, M. Matzuk, and L. Yen. A recurrent BCAM-AKT2 fusion gene leads to a ...

Le mécanisme catalytique du splicéosome est encore inconnu, mais par analogie avec le fonctionnement du ribosome, on pense que c'est l’ARN qui est catalytique (et donc que le splicéosome est un ...