Here's everything you need to know for Week 3 NFL games. Which teams will win? Who are the X factors, and which storylines ...

Brandon Aiyuk caught four passes for 43 yards in the San Francisco 49ers' Week 2 loss to the Minnesota Vikings. While it may ...

The San Francisco 49ers have provided new injury updates ahead of Thursday's practice, adding two more key players to the ...

San Francisco 49ers running back Christian McCaffrey missed most of training camp and the entire preseason due to a calf strain and Achilles tendinitis, the latter of which kept him out of Week 1. On ...

San Francisco 49ers safety Talanoa Hufanga is poised to make his season debut on Sunday against the Los Angeles Rams.

The San Francisco 49ers will be missing two of their biggest playmakers when they visit SoFi Stadium on Sunday to face the ...

The San Francisco 49ers are preparing for their Week 3 contest against the Los Angeles Rams on Sunday at SoFi Stadium in ...

The 49ers will face the Rams on Sunday, for the first time since first-ballot, Deion-Sanders-Upper-Room Hall of Famer Aaron ...

San Francisco 49ers defensive coordinator Nick Sorensen, offensive line/run game coordinator Chris Foerster, and quarterback ...

San Francisco 49ers running back Christian McCaffrey will practice on Wednesday, though he will once again be limited.

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been ...

Football, they say, is a war of attrition. For the 49ers and the Rams, attrition has arrived with a capital A.The latest name ...