When cinacalcet is used, dose-modification of concomitantly administered drugs metabolized by CYP1A2, CYP2C9, CYP2C19 and CYP3A4 is not necessary. Cinacalcet does not pharmacokinetically interfere ...

Reported adverse drug events have increased from 30,000 to ... competitive inhibition of CYP2C19 Increased sedative effect [47] CYP3A4-mediated interactions Ketoconazole ↑ PPI effect Inhibition ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

观点一：阿奇霉素可明显干扰茶碱代谢，使茶碱血液浓度升高；两者不可联用。 茶碱在人体内通过肝药酶 CYP450 中的 CYP3A4、CYP1A2 进行代谢，而大环内酯类是 CYP3A4 及 CYP1A2 的抑制剂 [1] 。对于 CYP3A4 及 CYP1A2 酶活性较低的个体，茶碱的基础代谢比正常群体慢 ...

ROCKVILLE, Md. & EDMONTON, Alberta-- ( BUSINESS WIRE )--Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH) (Aurinia or the Company) today announced that the Japanese Ministry of Health, Labour, and Welfare ...

Biologics are drugs made from complex molecules manufactured using living microorganisms, plant, or animal cells. Many are produced using advanced biotechnology techniques. Biologics are sometimes ...

Could Taking Certain Drugs Reduce Risk of Ruptured Brain Aneurysm? June 5, 2024 — A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding ...

But if you consume too much of grapefruit, it can block the action of CYP3A4. If this happens, more of the medicine can enter the blood and stays in the body for a longer period of time. For instance, ...

Parkinson’s disease is a condition that damages dopamine-producing brain cells, leading to tremors, stiffness, and difficulty with balance and coordination. Medications for Parkinson’s disease aim to ...

If you have a higher A1C or if metformin alone is not enough to meet your A1C and blood sugar goals, your doctor may prescribe a combination of medications. Each type of diabetes medication can ...

After hours: September 27 at 6:29 PM EDT Loading Chart for DRUG ...

Here authors engineer macrophages that are targeted to glypican-3-expressing tumour cells and equipped with drug-loaded exosomes and show therapeutic efficiency in a mouse model of hepatocellular ...