观点一：阿奇霉素可明显干扰茶碱代谢，使茶碱血液浓度升高；两者不可联用。 茶碱在人体内通过肝药酶 CYP450 中的 CYP3A4、CYP1A2 进行代谢，而大环内酯类是 CYP3A4 及 CYP1A2 的抑制剂 [1] 。对于 CYP3A4 及 CYP1A2 酶活性较低的个体，茶碱的基础代谢比正常群体慢 ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

The most common manifestation of pharmacokinetic interactions with warfarin involves the inhibition or induction of its metabolism. Attention should be paid to the relative importance of the ...

Q: What is the Cyprus Pound worth against the Euro? A: One Cyprus Pound is worth INF Euros today Q: Is the Cyprus Pound going up or down against the Euro? A: Today's exchange rate (INF) is the ...