观点一：阿奇霉素可明显干扰茶碱代谢，使茶碱血液浓度升高；两者不可联用。 茶碱在人体内通过肝药酶 CYP450 中的 CYP3A4、CYP1A2 进行代谢，而大环内酯类是 CYP3A4 及 CYP1A2 的抑制剂 [1] 。对于 CYP3A4 及 CYP1A2 酶活性较低的个体，茶碱的基础代谢比正常群体慢 ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for ...

Aristada is a prescription drug used for schizophrenia. Find out about possible interactions with alcohol, other drugs, ...

One key enzyme is cytochrome P450 3A4, or CYP3A4. As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of ...

陈俊延说，抑制药物代谢的作用因人而异，可能长达数天或仅几个小时都有，吃完柚子相隔4小时也无法完全避免。对于肾功能不良的病人，服用慢性疾病用药更要考虑药物排除体外的速率，若是饮食突然改变，疾病控制可能会有变化。

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for co-administration of ritonavir Phase 2a study expected ...

The most common manifestation of pharmacokinetic interactions with warfarin involves the inhibition or induction of its metabolism. Attention should be paid to the relative importance of the ...

Many of these drugs are metabolized by cytochrome P450 3A4 (CYP3A4), which has been estimated to be involved in the metabolism of ∼50% of prescription drugs and is therefore a common cause of ...

DRUG INTERACTIONS: Strong cytochrome P450 3A4 inhibitors (e.g., ritonavir, ketoconazole): Use not recommended. May increase risk of systemic corticosteroid effects. USE IN SPECIFIC POPULATIONS: ...

常用药物包括奈玛特韦利托那韦（Paxlovid）、阿兹夫定、莫诺拉韦、先诺特韦利托那韦、氢溴酸氘瑞米德韦、来瑞特韦、阿泰特韦利托那韦等，一般适用于轻、中症且伴有进展为重症高风险因素的成年患者，且应尽早用药，在症状首次出现的57天内使用为宜。