This independent dataset consists of total 146 molecules, where 92, 74, 41, 47 and 49 molecules have metabolic specificity for CYP 3A4 ... predicted CYP isoform substrates; specificity is the ...

Many of these drugs are metabolized by cytochrome P450 3A4 (CYP3A4), which has been estimated ... that atorvastatin and its metabolites are substrates of OATP1B1. The label also states that ...

The sites at which interactions can occur, and the sites of action of important mediators of interactions, ATP-binding cassette transporter B1 (ABCB1) and cytochrome P450 3A4 isoform (CYP3A4), are ...

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with CANNABIS Some medications are changed and broken down by the liver. Cannabis might change how quickly the ...

Use of a statin not metabolized through the cytochrome P450-3A4 system may be appropriate in this setting.

This is because grapefruit juice interacts with an enzyme in the intestines called cytochrome P450 3A4 (CYP3A4), which is responsible for breaking down many different types of drugs. Compounds ...

Drug Interactions with Strong Cytochrome P450 3A4 Inhibitors Use caution when considering using ketoconazole and other known strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin ...

Drug Interactions with Strong Cytochrome P450 3A4 Inhibitors Use caution when considering using ketoconazole and other known strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin ...