Hot Spot. GWAS of tau PET scans found a single locus where SNPs (circles) were associated with higher tangle loads. The strongest signal came from SNP rs2113389 (gray diamond). [Courtesy of Nho et al.

A study published in the peer reviewed journal Cannabis and Cannabinoid Research and available online through the U.S. National Library of Medicine explores the effects of Cannabistilbene I (a ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

Despite knowing that the active centres of many metalloprotein enzymes are iron porphyrin ... can mimic the activity of various types of cytochrome P450. Can the catalytic activity and reaction ...

When metabolism of cinacalcet by the cytochrome P450-related liver enzyme CYP3A4 is inhibited by ketoconazole, itraconazole, voriconazole, telithromycin or ritonavir, cinacalcet dose should be ...

The compressed "non-bonded" interactions of the pre-reactive substrate on the active site of this enzyme, and the conformational dynamics, have been experimentally probed at high resolution. Analogous ...

One key enzyme is cytochrome P450 3A4, or CYP3A4. As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of ...

Did you know CBD is not for everyone? Cannabidiol (CBD) has gained significant popularity in recent years, touted for its potential therapeutic benefits and widely available in various forms, from ...

Aristada is a prescription drug used for schizophrenia. Find out about possible interactions with alcohol, other drugs, ...

The study explored the role of the cytochrome P450 2D6 (CYP2D6) enzyme, which is involved in metabolizing LSD. Participants with lower CYP2D6 activity had higher blood plasma concentrations of the ...

United Therapeutics Corporation (Nasdaq: UTHR), a public benefit corporation, today announced that five presentations and one poster across its commercial and development portfolio will be presented ...

Most guidelines say that either of these medicines is an appropriate first choice for high blood pressure (hypertension).