Mutations in the αB-crystallin (CRYAB) gene, encoding a small heat shock protein with chaperone function, are a rare cause of myofibrillar myopathy with autosomal-dominant inheritance, late-onset and ...

The World Health Organisation has linked air pollution to an estimated seven million deaths annually, and recognising it as the leading environmental risk factor globally. PM2.5, a major air pollutant ...

Patients are ineligible if they: (1) have complicated neck or shoulder pain caused by cervical and intervertebral disc degeneration, such as other types of cervical spondylosis, shoulder periarthritis ...

Myofibrillar proteins begin to denature at around 104 to 158 degrees Fahrenheit (40 to 70 degrees Celsius). As heat continues to be applied, these proteins refold and form a "gel" — a 3D protein ...

Myogenic progenitors (MPCs) are a specialized type of precursor cell responsible for the formation of skeletal muscle cells during embryonic development. The process begins with the transformation of ...

Introduction: Patients with Cushing’s syndrome (CS) in remission show sustained fatigue, myopathy, and an increased prevalence of sarcopenia. The mechanisms that determine these persistent muscle ...

Leucine is an essential branched-chain amino acid (BCAA) that some research suggests may help improve muscle mass, athletic recovery, inflammation, and blood sugar levels. However, further studies are ...

1 Department of Orthopedics and Sports Medicine, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, China 2 Department of Orthopedics and Sports Medicine, Northern Jiangsu ...

Patrick J. Perik, MD, PhD, Maarten Alexander de Korte, MD, PhD, Dirk J. van Veldhuisen, MD, PhD, Jourik A. Gietema, MD, PhD, Dirk T. Sleijfer, MD, PhD and Elisabeth G ...

Am J Health Syst Pharm. 2009;66(10):908-915. As critically ill patients receive numerous drugs to treat a wide variety of complicated health problems, they are at high risk for adverse drug events ...

Indeed, histological, immunohistochemical and western blot studies on muscle samples are generally adequate to distinguish among different LGMDs due to lack of sarcolemmal protein or to identify ...