环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应元件结合蛋白(cAMP/PKA/CREB)信号通路：环磷酸腺苷在各种反馈机制和细胞信号转导中是 ...

Studies utilizing inhibition and activation of intracellular signalling proteins have shown that transcription factors including CREB ... protein kinases including PKA and ERK, are required ...

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AC, Adenylate Cyclase; AKT/PKB, Protein Kinase B; Bcl2, B-cell lymphoma 2; cAMP, Cyclic Adenosine Monophosphate; CREB, cAMP Response Element-Binding Protein; EPAC2, Exchange Protein directly Activated ...

2024年9月4日，中国科学院生物物理研究所陈畅研究组与中国科学院上海药物研究所丁侃研究组合作，在《The FASEB Journal》杂志在线发表了题为"Lycium barbarum...

Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...

Inhibition of melanogenesis by 3-(1'-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone via suppressing the activity of cAMP response element-binding protein (CREB) and nuclear exclusion of ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

Here, we report that Wnt3a either induces O-GlcNAcylation rapidly via the Ca 2+-PKA-Gfat1 axis, or increases it in a Wnt-β-catenin-dependent manner following prolonged stimulation. Importantly, we ...