Meier and coauthors found that topotecan improved progression-free and overall survival compared with treosulfan in patients with recurrent ovarian cancer following platinum and taxane-based therapy.
6 Another trial has demonstrated superior overall survival for patients treated with topotecan and cisplatin compared with paclitaxel and cisplatin. 5 The GOG-204 trial demonstrated similar ...
Four CPT analogs, namely trastuzumab derukstekan, topotecan, belotecan, and irinotecan, have been approved as part of chemotherapy treatments. However, the investigation continues into their ...
AbbVie (NYSE: ABBV) today announced that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending the marketing ...
Present anti-cancer drugs — camptothecin, topotecan, and irinotecan — target a molecule (the enzyme topoisomerase 1 or Top1) involved in DNA metabolic processes like replication and transcription.
Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...