Another new target is cathepsin K, a cysteine protease that is abundantly expressed in osteoclasts. Odanacatib (Merck), the most advanced compound in this class, is currently in Phase III studies ...
Researchers from the National Center for Nanoscience and Technology and Chongqing Medical University developed three types of nanostructures that combine L-phenylalanine with metal ions. This ...
In addition, the researchers found that the uptake of nanostructures by DCs may induce the release of cathepsin B, which, along with the outflow of potassium ions, activates the inflammasome ...