The recent advances in high-throughput sequencing studies, integrated with findings derived from multimodal brain imaging data analyses and genome-wide association studies (GWAS) have expanded our ...
MR-Base enables automation of two-sample MR using 11 MR methods (including MRC-IEU methods addressing pleiotropy). We are working with various pharmaceutical companies on approaches to prioritise drug ...
The researchers found that this was due to both pleiotropy (a gene affecting multiple traits) and trade-offs (one trait cannot decrease without another increasing). “While pleiotropy has been ...
A particular interest is in identifying pleiotropy (when a single gene influences two or more seemingly unrelated physical traits) and environmental modifiers of genetic associations, including ...
The primary objective of this research is to develop MR to: Address the recognized limitations of MR through development of a range of approaches, to address issues such as limited statistical power, ...