Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical ...

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical regions of the central nervous system, such as the pons, thalamus, and spinal ...

Epigenetics regulates gene expression through modifications, impacting health and disease. Aberrant patterns can lead to ...

Keywords: human GI tract, gut microbiome, host genetics, host epigenetics, epi-transcriptomics, GI homeostasis, microbiome-derived metabolites, DNA methylation, histone acetylation Important Note: All ...

However, how post-translational modifications regulate syn function remains unclear. In this manuscript, Wang et al. reported an exciting discovery that N-acetylation of syn enhances the clustering of ...

Post-translational modifications (PTMs) of α-synuclein (α-syn) such as acetylation and phosphorylation play important yet distinct roles in regulating α-syn conformation, membrane binding, and amyloid ...

Hepatic HNF4α loses its function during sepsis due to alterations in its chromatin binding. These changes in HNF4α chromatin ...

The findings demonstrate the essential contribution of the microtubule network to changes in cell shape driven by mechanical forces. Furthermore, we observed a flow-dependent increase in microtubule ...

Decreased SIRT1 expression was detected in RA ECs and synovial vessels. Deficient endothelial SIRT1 expression promoted a proliferative, proapoptotic and activated state of ECs through the acetylation ...

The time slot for the cleavage of methionine and the subsequent acetylation to occur smoothly is quite short. During this time, several enzymes must be brought to the right place and be regulated ...