耐药性能通过降低许多长期疗法的疗效，从而给很多乳腺癌患者带来了一大治疗难题，尽管一种特定的疗法能杀死大多数癌细胞，但仍然有很小一部分比例的癌细胞对疗法会产生一定的耐药性，并能使其存活、生长和扩散。癌细胞的生存和生长的能力依赖于细胞增殖和细胞死亡之间的 ...

Apoptotic DNA degradation has been thought to be a cell-autonomous process. Recent evidence suggests that heterophagic recognition and engulfment of dying cells by non-apoptotic cells may be ...

Using immunomarkers of axonal pathology [β-amyloid precursor protein (β-APP) and apoptotic marker fractin], we tested the hypothesis that widespread (diffuse) axonal injury occurs in the gliotic ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of ...

Elahere was found to improve survival in patients with FR-alpha–positive, platinum-resistant, high-grade serous epithelial ...

These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...

The results of the referenced study show an increase in the stimulation of the apoptotic cascade in hepatocytes, the magnitude of which strongly correlates to the absolute amount of the a1AT mutant Z ...

Bile acids are byproducts of cholesterol metabolism in the liver and constitute the primary components of bile. Disruption of ...

IGM Biosciences has collaboration deal with Sanofi inked in 2022 and its stock has almost doubled in 2024 year to date. Read ...

The inhibition of ERK5 is a potential complementary strategy for countering FAK inhibitor resistance in patients with lung ...

However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation ...

Although the role of innate immune sensing pathways is well-studied in the pathogenesis of malignancies, whether they ...