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腾讯网
6 小时
阿奇霉素 + 复方甲氧那明,这个医嘱错在哪?
观点一:阿奇霉素可明显干扰茶碱代谢,使茶碱血液浓度升高;两者不可联用。 茶碱在人体内通过肝药酶 CYP450 中的 CYP3A4、CYP1A2 进行代谢,而大环内酯类是 CYP3A4 及 CYP1A2 的抑制剂 [1] 。对于 CYP3A4 及 CYP1A2 酶活性较低的个体,茶碱的基础代谢比正常群体慢 ...
Medscape
19 小时
Utilization of Pharmacogenomics and Therapeutic Drug Monitoring for Opioid Pain Management
Aims: The use of medication in pain management currently involves empirical adjustment based on observed clinical outcome and the presence of adverse drug reactions. In this study ...
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