The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...
One key enzyme is cytochrome P450 3A4, or CYP3A4. As the furanocoumarins in grapefruit are broken down in the body, their resulting derivatives can block the action of CYP3A4. Thus, instead of ...
The most common manifestation of pharmacokinetic interactions with warfarin involves the inhibition or induction of its metabolism. Attention should be paid to the relative importance of the ...
Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for co-administration of ritonavir Phase 2a study expected ...
Many of these drugs are metabolized by cytochrome P450 3A4 (CYP3A4), which has been estimated to be involved in the metabolism of ∼50% of prescription drugs and is therefore a common cause of ...
DRUG INTERACTIONS: Strong cytochrome P450 3A4 inhibitors (e.g., ritonavir, ketoconazole): Use not recommended. May increase risk of systemic corticosteroid effects. USE IN SPECIFIC POPULATIONS: ...