观点一：阿奇霉素可明显干扰茶碱代谢，使茶碱血液浓度升高；两者不可联用。 茶碱在人体内通过肝药酶 CYP450 中的 CYP3A4、CYP1A2 进行代谢，而大环内酯类是 CYP3A4 及 CYP1A2 的抑制剂 [1] 。对于 CYP3A4 及 CYP1A2 酶活性较低的个体，茶碱的基础代谢比正常群体慢 ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, ...

常用药物包括奈玛特韦利托那韦（Paxlovid）、阿兹夫定、莫诺拉韦、先诺特韦利托那韦、氢溴酸氘瑞米德韦、来瑞特韦、阿泰特韦利托那韦等，一般适用于轻、中症且伴有进展为重症高风险因素的成年患者，且应尽早用药，在症状首次出现的57天内使用为宜。

目的：综述孕烷X受体（PXR）和组成型雄甾烷受体（CAR）-代谢酶/转运体解毒系统的功能和研究进展。 方法：从肝脏代谢酶、肝 ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for co-administration of ritonavir Phase 2a study expected ...

Panax ginseng, a variety of the herb ginseng, has been touted for several health benefits, including lowering cholesterol, reducing inflammation, and managing blood glucose levels. However, there is ...

These medications that attach to CYP450 proteins are called substrates. Devil's claw may affect how specific CYP450 proteins work—particularly the CYP2C9, CYP2C19, and CYP3A4 proteins. Changing how ...

Our data set consists of 449 SNPs distributed in the 57 CYP450 genes. FastSNP analysis predicted the functional impact of these genetic variants: 47.9% of the SNPs have no known function ...

陈俊延说，抑制药物代谢的作用因人而异，可能长达数天或仅几个小时都有，吃完柚子相隔4小时也无法完全避免。对于肾功能不良的病人，服用慢性疾病用药更要考虑药物排除体外的速率，若是饮食突然改变，疾病控制可能会有变化。

Aristada is a prescription drug used for schizophrenia. Find out about possible interactions with alcohol, other drugs, ...

Note: Parallel guidance has been provided to community and hospital paediatric services and accompanies this guidance. Where a referral is made to the NHS CYP Gender Service, your service is asked to ...