Hot Spot. GWAS of tau PET scans found a single locus where SNPs (circles) were associated with higher tangle loads. The strongest signal came from SNP rs2113389 (gray diamond). [Courtesy of Nho et al.

Study demonstrates that glutathione (GSH) significantly reduces acetaldehyde levels, a key factor in hangovers, though ...

The gene was, therefore, named HYPERSENSITIVE TO LOW P1 (HYP1). HYP1 is a member of the CYBDOM family and possesses a cytochrome b561 domain, which is common in several ferric reductases active in ...

Ratutrelvir was well-tolerated for 10 days and achieved consistent plasma levels in the predicted therapeutic window, without the need for ...

David Bickar’s research has diverged into three distinct areas. The first focuses on the mechanisms of electron transfer and oxygen reduction, and the proteins that catalyze these reactions. Much of ...

Secondary efficacy analyses of the pivotal SEQUOIA-HCM trial continued to favor aficamten, supporting a potential role for ...

Rates of amino acid changes in fibrinopeptides, hemoglobin, and cytochrome c. The three proteins show different rates of changes per unit time. However, for each protein, the rate of changes per ...

A team of international researchers has uncovered a new species of land flatworm in the United States, adding to the growing ...

Curcumin has an estimated bioavailability of 65% after oral administration. It inhibits cytochrome P-450 isoenzyme 1A1 and is metabolized by glucuronidation. [13] Neither turmeric nor curcumin has ...

coli oxidase (cytochrome bd). He also showed the unique functional capabilities of this oxidase, including its remarkably high affinity for oxygen and its role in protecting E. coli from nitric oxide.

The study explored the role of the cytochrome P450 2D6 (CYP2D6) enzyme, which is involved in metabolizing LSD. Participants with lower CYP2D6 activity had higher blood plasma concentrations of the ...