In July, Biogen and Sage reported the failure of GABAA receptor positive allosteric modulator SAGE-324, also called BIIB124, ...

Sage Therapeutics announced that Biogen has ended its partnership on the SAGE-324 program after the drug failed in a Phase II ...

Taateewwan akkasii erga mudatanii yeroo muraasa booda wayita giddugala gabaa keessatti dhohiinsi mudatu viidiyoon agarsiisa.

Sage Therapeutics, Inc. (Sage) announced Thursday that Biogen Inc. (BIIB) has terminated its rights under the collaboration and ...

Fintel reports that on September 23, 2024, Oppenheimer upgraded their outlook for Marinus Pharmaceuticals (NasdaqGM:MRNS) ...

作为一种天然的异黄酮类化合物，葛根素在临床上被用于治疗心脑血管疾病。对小鼠DMV脑片的电生理试验结果显示，葛根素可显著降低动作电位频率。而在脑室内注射葛根素后，小鼠体重降低，原因在于肠道的脂肪吸收受到了抑制，脂肪排泄增加。这些结果表明葛根素可以抑制D ...

【导读】肿瘤微环境中的一些代谢物可以改变固有免疫功能。9月26日，武汉大学李友军教授研究团队在期刊《Advanced Science》上发表了研究论文，题为“Increases in 4-Acetaminobutyric Acid Generated ...

The company’s Phase 3 study design improvements, informed by earlier Phase 2 results, along with the drug’s mechanism of action which targets both synaptic and extrasynaptic GABAA receptors, suggest a ...

该研究表明，肠道对脂肪的吸收受到大脑直接调控，抑制这条“脑-肠轴”，会导致小肠上皮细胞的微绒毛缩短，从而缩小吸收表面积，减少对脂肪的吸收，增加脂肪通过粪便的排除，从而促进体重减轻。该研究还展示了来自中药葛根的天然化合物葛根素（puerarin）可以靶 ...

Manneen dhugaatii fi kilabiiwwan cufee, jiddugalawwan gabaa nyaataan ala waan dhibii gurguranis akka cufaman ajajeera. Manneen nyaataas warra qe'eetti fudhatanii galan qofa keessummeessu jedhe ibsi ...

9月11日，上海交通大学医学院附属瑞金医院王卫庆、王计秋团队在顶级期刊《Nature》上发文，研究发现大脑能够通过“脑-肠轴”通道直接调控肠道的脂肪吸收，同时确定了葛根提取物— 葛根素 ...

该研究发现了一种天然化合物葛根素，它可以模拟DMV-迷走神经通路的抑制，从而减少脂肪吸收。光亲和化学方法和冷冻电子显微镜对GABAA受体-葛根素复合物结构的研究表明，葛根素结合到一个变构调节位点。值得注意的是，DMV中的条件性Gabra1敲除在很大程度上消除了葛根素诱导的肠道脂肪损失。总之，该研究发现抑制DMV-迷走-空肠轴通过缩短微绒毛长度来控制肠道脂肪吸收，并说明葛根素与GABRA1结合在减脂 ...