By Pooja Toshniwal Paharia Managing risk factors related to loneliness could still improve long-term health outcomes, ...

A recent study led by researchers from the University of Edinburgh, UK and published in the journal Molecular Psychiatry ...

ILC Therapeutics has completed a fundraise worth £2.5m. Led by Eos, Scottish Enterprise, Medical Incubator Japan and Los Angeles-based lawyer and investor Robert Kopple, the money will support the ...

MR results can be biased by horizontal pleiotropy, but there are methods available to detect and allow for pleiotropy. We undertook a bidirectional MR analysis to test whether there is a causal ...

MR pleiotropy and Cochran’s Q test were used to confirm the heterogeneity and pleiotropy of identified IVs, then four different models, including the inverse variance weighted model (IVW), MR-Egger, ...

The researchers found that this was due to both pleiotropy (a gene affecting multiple traits) and trade-offs (one trait cannot decrease without another increasing). “While pleiotropy has been ...

Bidirectional MR analysis was conducted using MR-Egger, Weighted Median, Simple Mode, Weighted Mode, and Inverse Variance Weighted (IVW) algorithms, and the robustness of MR results was assessed ...

We suggest that paralogs can overcome the obstacle of structural pleiotropy by regulatory evolution at the transcriptional and post-translational levels. Mutations in paralogous proteins originating ...