Sepsis mortality, including a 28-day mortality, is associated with a genetic predisposition to gastroesophageal reflux disease.

演化生物学家乔治·威廉姆斯在1953年就提出了拮抗基因多效性（antagonistic pleiotropy）假设，认为自然选择让促进繁殖成功的基因更加丰富，但也在 ...

MR-Base enables automation of two-sample MR using 11 MR methods (including MRC-IEU methods addressing pleiotropy). We are working with various pharmaceutical companies on approaches to prioritise drug ...

The recent advances in high-throughput sequencing studies, integrated with findings derived from multimodal brain imaging data analyses and genome-wide association studies (GWAS) have expanded our ...

The researchers found that this was due to both pleiotropy (a gene affecting multiple traits) and trade-offs (one trait cannot decrease without another increasing). “While pleiotropy has been ...

One of the leading explanations for why is that the genetic mutations that favour reproducing earlier in life could also ...

A study reveals loneliness correlates with 13 illness categories, highlighting its role as a potential proxy marker rather ...

A particular interest is in identifying pleiotropy (when a single gene influences two or more seemingly unrelated physical traits) and environmental modifiers of genetic associations, including ...

The primary objective of this research is to develop MR to: Address the recognized limitations of MR through development of a range of approaches, to address issues such as limited statistical power, ...

The following is a summary of “Causal relationships between gut microbiome and aplastic anemia: a Mendelian randomization ...